Another study used a tissue microarray to detect CLDN18.2 IHC staining in samples from patients with non-small-cell lung cancer (NSCLC) [55] and revealed distinct membranous positivity of CLDN18.2 (3.7%) in nonoverlapping subgroups of adenocarcinomas and large-cell carcinomas. The gene discussed is CLDN18; the disease is large cell carcinoma.