As shown in Fig. 4F and G, the ratio of ipsilateral/contralateral hemisphere volume in RGD-PLT@PLGA-FE treated mice was 87.93 ± 7.40%, which was significantly higher comparing to that of 10% sucrose-treated, FE-treated, PLGA-treated, PLGA-FE-treated, PLT@PLGA-treated, and RGD-PLT@PLGA-treated mice, suggesting RGD-PLT@PLGA-FE treatment reduced brain atrophy volume of mice at 14 days after stroke. The gene discussed is NAAA; the disease is Stroke.