Importantly, coomassie brilliant blue staining and Western Blot results showed PLTs membrane-related surface proteins including CD62p and CD41 were still displayed in RGD-PLT@PLGA-FE nanoparticles (Fig. 1F and G) and no significantly difference among the three groups (Fig. 1H and I), warranting further investigation for their targeting and therapeutic role in stroke. The gene discussed is ITGA2B; the disease is Stroke.