NAAA and ischemic stroke: To investigate the possible reason why RGD-PLT@PLGA-FE treatment achieved the best therapeutic effects for ischemic stroke, angiogenesis and neurogenesis of ischemic mice treated with 10% sucrose, FE only, PLGA-FE, PLT@PLGA-FE, RGD-PLT@PLGA, and RGD-PLT@PLGA-FE were examined by immunohistochemistry (Fig. 5A and B).