In those days, research on the pathogenesis of FXTAS is at a standstill since the repeat expansion is confined to the 5’UTR of FMR1 [51], despite the fact that CGG repeat expansion is believed to be essential, as said by Ammar Al-Chalabi when the pathogenic locus of C9ORF72 was uncertain, “It’s like we knew the street, but we didn’t know the exact house” [25]. Here, FMR1 is linked to fragile X-associated tremor/ataxia syndrome.