Indeed, only 2 of 13 mLCD studies (15.4%) excluded patients at a higher risk of hypoglycemia with type 1 diabetes or those using insulin or sulfonylureas [59, 74–78], compared to 4 of 5 VLCD studies (75.0%) [38, 45, 51, 67] in our analysis. The gene discussed is INS; the disease is Hypoglycemia.