The proportions of individuals with previous hypertension, ischemic cardiomyopathy (IMD), DM and hyperlipidemia were significantly higher in the highest TyG index tertile, as well as BMI, FPG, HbA1C, CRP, UA, hematocrit, WBC, ALB, total cholesterol, triglyceride, LDL-C and hemoglobin levels; antiplatelet agent, statin, insulin, metformin, sodium-glucose cotransporter 2 inhibitor (SGLT2i) and other hypoglycemic drugs uses were also enhanced (all p < 0.05). The gene discussed is SLC5A2; the disease is ischemic cardiomyopathy.