Alzheimer’s disease (AD), the most common type of dementia, is neuropathogically characterized by the presence of hyperphosphorylated tau in intraneuronal neurofibrillary tangles, the deposition of amyloid-β (Aβ) in the brain parenchyma and cerebral vasculature, and the gradual loss of synapses which is the best pathological correlate with cognitive impairment [1, 2]. This evidence concerns the gene MAPT and Alzheimer disease.