To further study the role of ATF2 in cancer cells with different p53 status, HCT-116-p53−/− and HCT-116-p53+/+ colon cancer cell lines over-expressing ATF2-WT (wild type), ATF2-T71A (inactivated), ATF2-T71E (activated) were treated with cisplatin. This evidence concerns the gene TP53 and malignant colon neoplasm.