The other important biological concerns include: (a) the widespread resistance of malaria vectors to public health insecticides, notably those used for insecticide treated nets (ITNs) and indoor residual spraying (IRS) [11]; (b) the emerging threat of parasite resistance to frontline malaria treatments [12, 13] and (c) the emergent failures of malaria rapid diagnostic tests (mRDTs) due to HRP2/3 gene deletions in Plasmodium falciparum [14]. This evidence concerns the gene HDGFL2 and malaria.