However, there are no data whether delirium is associated with M1 macrophage, Th1, Th2, Th17, Treg or CIRS cytokine profiles, and whether a neurotoxic cytokine profile including M1, Th1, Th17 and neurotoxic chemokines, such as CCL11, CCL2, CCL3, CCL5, and CXCL10) is associated with delirium. This evidence concerns the gene CCL2 and delirium.