Hence, the aims of this study were to delineate a) the cytokine profiles (including M1 macrophage, Th1, Th2, Th17, Treg, Tcell growth) of delirium due to hip fracture; b) whether a neurotoxic cytokine/chemokine profile consisting of M1, Th1, Th17 cytokines and the neurotoxic CCL11, CCL2, CCL3, CCL5, CXCL8 and CXCL10 chemokines are associated with delirium. This evidence concerns the gene CCL3 and delirium.