Moreover, increased neurotoxicity due to the cumulative effects of M1 macrophage, T helper (Th)1, and Th17 phenotypes and neurotoxic cytokines/chemokines e.g., CCL11, CCL2, RANTES (CCL5), CXCL10 (IP-10) and CCL3 (macrophage inflammatory protein 1α) to a large extent explain the symptoms and cognitive impairments of the major psychoses [24, 29–32] and, therefore, could be involved in the pathophysiology of delirium. This evidence concerns the gene CCL5 and Cognitive impairment.