These findings extend those of previous papers showing that alterations in peripheral levels of IRS cytokines, namely IL-1β, IL-6, CXCL8, IL-10, and TNF-α, and also C-reactive protein (CRP) and NLR are associated with the onset of delirium [3, 18, 19, 35, 36]. The gene discussed is IL1B; the disease is delirium.