Because SPARC regulates cell–matrix interactions and also regulates the activity of many growth factors, such as fibroblast growth factor (FGF)-2, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) [4], it could play a significant role in leiomyoma pathogenesis. The gene discussed is FGF2; the disease is leiomyoma.