Although our study showed decreased expression of COMTD1 mRNA in leiomyomas, another member of the methyltransferase superfamily, COMT, (catechol-O-methyltransferase) which is involved in metabolism of steroid hormones was reported to be overexpressed in uterine leiomyomas with higher frequency of COMT Val158Met genotype in African Americans [78, 79]. The gene discussed is COMTD1; the disease is leiomyoma.