AKT1 and leiomyoma: KEGG pathway analysis of the differentially expressed SE-associated mRNAs revealed that multiple signaling pathways such as proteoglycan synthesis pathway, estrogen signaling, PI3K-AKT, TGF-β (transforming growth factor beta) signaling, and the signaling pathways involving Th1, Th2, and Th17 cell differentiation which are all relevant to leiomyoma pathogenesis were altered in leiomyomas.