Most importantly, the group of Sophie Lotersztajn elegantly demonstrated that the lack of MAIT cells in MR1−/− mice protects against liver fibrosis in a model of carbon tetrachloride (CCl4)-induced liver injury; conversely, increased amounts of MAIT cells in MAIT-TCR transgenic mice enhanced liver fibrosis [5]. Here, MR1 is linked to Hepatic fibrosis.