The two major EGFR alterations in IAC were EGFR L858R (34.4% vs. 9.8% vs. 28.2%; P < 0.01; Fig. 2E) and exon 19 deletion (19del; 28.1% vs. 7.7% vs. 19.4%; P < 0.01; Fig. 2E), whereas EGFR 20ins was the most predominant EGFR alteration in AIS with a mutation rate of 8.1% compared to 4.2% in MIA, and 3.2% in IAC (Fig. 2E). The gene discussed is EGFR; the disease is androgen insensitivity syndrome.