Comparative analyses demonstrated that AIS had similar frequencies of EGFR L858R, 19del, and 20ins (9.8% vs. 7.7% vs. 8.1%, P = 0.762), whereas MIA and IAC had statistically more predominant EGFR L858R and 19del than EGFR 20ins (MIA, 28.2% vs. 19.4% vs. 4.2%, P < 0.001; IAC, 34.4% vs. 28.1% vs. 3.2%, P < 0.001), suggesting the distinct patterns of EGFR driver mutations across tumors of varying invasion levels (Fig. 4A). The gene discussed is EGFR; the disease is androgen insensitivity syndrome.