ACTA2 and myocardial infarction: One other important observation of our integration approach was the different occurrence of Thbs4+ high ECM expressing fibroblasts and Acta2+ myofibroblasts, with the latter clearly found early after myocardial infarction (MI)15, though not in the TAC (our data) nor AngII model23 (Supplementary Fig. 6i–l).