SLC1A5 and neoplasm: Consistent with the in vitro results showing that SPOP levels decreased while ASCT2 levels increased upon glutamine starvation, we found low levels of SPOP and high levels of ASCT2 were coupled with decreased glutamine concentrations and increased glutamate/glutamine ratio in tumor tissues, as compared to paired normal counterparts (Fig. 7, Supplementary Fig. 9).