SPOP and cancer: We further performed the Kaplan-Meier survival analysis among 92 cancer samples with the inverse correlation between the levels of SPOP and ASCT2, and found high SPOP/low ASCT2 (n = 39) predicted a better patient survival, whereas low SPOP/high ASCT2 (n = 53) was associated with worse survival of breast cancer patients (Fig. 7f).