Notably, BRCA1 restoration in both MDA-MB-436 and HCC1937 cells significantly inhibited the up-regulation of CD163 with little effect on the reduction of CD86 in THP1 macrophages, suggesting that BRCA1 restoration reduced the ability of BRCA1-deficient breast tumor cells to promote the M2-like polarization (Supplementary Fig. 2g, i). This evidence concerns the gene BRCA1 and breast neoplasm.