Further, gene set enrichment analysis (GSEA) of signatures or signaling pathways associated with M2-like macrophage polarization or an immunosuppressive TIME32,33, such as epithelial mesenchymal transition (EMT), STAT3 targets, angiogenesis, hypoxia, TGF-beta signaling, and KRAS signaling, were upregulated in BRCA1-mutant breast tumors compared to BRCA1-mutant ovarian tumors (Supplementary Fig. 1n, o). The gene discussed is BRCA1; the disease is ovarian neoplasm.