Previous studies revealed that CALR enhanced EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway [17] and repressed E-cadherin expression via Snail (SNAI1)/Slug in Madin-Darby canine kidney cells or mouse embryonic stem cells [18, 19]. This evidence concerns the gene CALR and familial pancreatic carcinoma.