Furthermore, we also determined that the increased expression of CALR was related to GC grade, postoperative recurrence, and tumor involvement of lymphatic vessels (Supplementary Fig. 1B–E) by analyzing Oncomine data (https://www.oncomine.org/), and overall survival analysis showed a worse survival rate in the GC patients with high CALR expression by Kaplan–Meier Plotter analysis (Fig. 1F) (http://kmplot.com/). This evidence concerns the gene CALR and neoplasm.