However, recently, it was suggested that variants located in EGFR domains 1–6 are associated with more severe disease than variants in domains 7–34, including earlier age at stroke onset, shorter survival, and increased white matter hyperintensity (WMH) volume.7 The initial study reported associations with age at onset of stroke in 251 Dutch patients with CADASIL, but these were yet to be confirmed in other ethnic groups of patients with CADASIL. This evidence concerns the gene EGFR and Stroke.