Of the 5 pathogenic Afro-Colombian mutations, 2 mutations, BRCA1_c.5123C>A 12 and BRCA2_c.2701delC, were previously reported in White/mestizo patients with BC,11 whereas the other 3 BRCA1 mutations, BRCA1_c.213-12A>G, c.4163_4164insA, and c.4203delT, were only detected in Afro-Colombians. The gene discussed is BRCA1; the disease is breast cancer.