It has been reported that African-American patients with BC are more likely to be affected at a younger age, have a more aggressive disease, and have a higher likelihood of dying from this disease than women from other ethnic groups.22 Additionally, it has been shown that African-American patients with BC harboring pathogenic BRCA1/2 mutations are younger at the age of diagnosis than noncarriers (median ages: 37 years vs 47 years).23 This is consistent with what was observed in our Afro-Colombian study, where the median age of BC onset among BRCA1/2 carriers was 40 and of 51 for noncarriers. The gene discussed is BRCA1; the disease is breast cancer.