BRCA1 and breast cancer: Approximately 10% of BC cases are due to genetic factors and associated with a family history, which can be attributed to germline mutations in BC susceptibility genes, in particular BRCA1 and BRCA2 (BRCA1/2).9,10 The contribution of BRCA1/2 germline mutations to early-onset and hereditary breast/ovarian cancer (OC) in the Colombian population was previously described by us in 2 studies conducted among a total of 121 White/mestizo breast/OC-affected families and unselected patients with BC.