This results in the loss of tumor-suppressor genes, the most common being von Hippel-Lindau (VHL), followed by Polybromo 1 (PBRM1), BRCA1-associated protein-1 (BAP1), and SET domain-containing protein 2 (SETD2).10-12 A comprehensive genomic study by The Cancer Genome Atlas research network of a kidney cancer cohort included 843 patients consisting of 488 ccRCCs, 274 papillary RCCs (n = 160 and n = 70 for type 1 and type 2, respectively), and 81 chromophobe RCCs.9 In ccRCC, a low expression level of AMPK and a high level of ribose sugar metabolism were associated with lower survival. The gene discussed is PBRM1; the disease is kidney cancer.