Simultaneous infection of stromal and tumor cells; Upregulation of Fez1 and Pycard; Downregulation of DLL-4, Angiopoietin 2, PECAM, Tie-1, and FOS EGR2, CREB-5, IL-6, Map2K1, CCL22, TIMD4 and CCL19. The gene discussed is FEZ1; the disease is neoplasm.