In analyses considering mediating effect of individual variables in the relationships between PAT and cardiovascular phenotypes, across all outcomes, significant mediation effect was observed with diabetes, high cholesterol, HDL cholesterol, triglyceride level, CRP, urate, and Apolipoprotein B. We summarize PAT-CMR associations and contributions to effects from each potential mediator in Figure 2 and see Supplementary data, Figure 2. This evidence concerns the gene CRP and diabetes mellitus.