In analyses considering mediating effect of individual variables in the relationships between PAT and cardiovascular phenotypes, across all outcomes, significant mediation effect was observed with diabetes, high cholesterol, HDL cholesterol, triglyceride level, CRP, urate, and Apolipoprotein B. We summarize PAT-CMR associations and contributions to effects from each potential mediator in Figure 2 and see Supplementary data, Figure 2. The gene discussed is APOB; the disease is diabetes mellitus.