Induced PSC-derived ECs generated from patients with T2D show restricted angiogenic potential, and produce higher amounts of the vasoconstrictor, Endothelin-1.82 Endothelial cells generated from iPSCs carrying mutation in MODY3 gene, HNF1A, showed a dose-dependent increase in vascular permeability to proinflammatory cytokines, which may contribute to endothelial dysfunction in some MODY3 patients due to a compromised barrier resulting in vascular leakage.83 The gene discussed is HNF1A; the disease is maturity-onset diabetes of the young type 3.