These include loci: for BMI, multiple lipids, red cell traits, non-syndromic metopic craniosynostosis at the PAR2 boundary [36–39]; ANCA-associated vasculitis, Alzheimer’s disease, non-syndromic metopic craniosynostosis, susceptibility to TB, 3-hydroxy-1-methylpropylmercapturic acid levels and adenosine diphosphate at PAR3 [36,40–45]; age of onset of myopia, mean corpuscular volume, eosinophil count, and asthma [43][39,46,47] close to PAR1/NPR boundary. This evidence concerns the gene NPTXR and early-onset autosomal dominant Alzheimer disease.