At 30, 60, 90, and 150 dpi, as shown in Fig 8A and 8B, as the infection ensued, the percentage of CD4+ IFN-γ+ cells was significantly higher than control at 30 dpi and reached a maximum at 60 dpi before decreasing; the CD4+ IL4+ cells percentage showed a gradual increasing and peaked at 90 dpi; the change of percentage of CD4+ IL-17A+ cells showed a similar trend to the percentage of CD4+ IFN-γ+ cells. This evidence concerns the gene IFNG and infection.