The dynamic change of Th1, Th2 and Th17 response related cytokines levels and percentages of Th1, Th2 and Th17-type cells in the infected liver in the present study exhibited a similar trend, which indicated that Th1 and Th17-type CD4+ T-cells were predominant at the early infection stage whereas Th2-type CD4+ T-cells were significantly higher at the middle/late stage. The gene discussed is CD4; the disease is infection.