IL4 and helminthiasis: Helminth infection can alter Th1/Th2 immune polarization, reduce systemic levels of Th1/Th17 pro-inflammatory cytokines (IL-4 over IL-17, TNF-α and IFN-γ), switch macrophages from M1 to M2 pattern, or change intestinal microbial diversity, all of which lead to increased insulin sensitivity [6, 39, 40].