AMFR and neoplasm: To evaluate the association between gp78 and multiple features within the tumor microenvironment, we used a multiomic approach that combined: (a) immune features of the tumor microenvironment inferred from available RNA-Seq data to estimate the relative abundance of different immune cell types using CIBERSORT as previously described (7, 76); (b) quantitative morphological assessment of the stromal and epithelial nuclear and cytoplasmic features (77, 78); and (c) IHC-based protein biomarker profiling (6, 11, 49, 50) (Figure 7).