GSEA using the RNA-Seq data of patients with breast cancer stratified by high versus low gp78 protein demonstrates that tumors expressing high levels of gp78 protein showed much greater activation of immunorelated, metabolic, cell-cycle, and other cell-stress adaptive pathways including the UPR and cholesterol homeostasis (Figure 3 and Supplemental Figure 3). Here, AMFR is linked to breast cancer.