To determine the predictive value of gp78 expression in mammary malignancies, we analyzed a previously established racially diverse breast cancer cohort of patients (n = 560) residing in a designated health disparities catchment area in Eastern North Carolina (median follow-up, 8.5 years) and arrayed in tissue microarray (TMA) format (6, 11, 49, 50) to define the association between gp78 protein levels and breast cancer patient tumor characteristics and survival. The gene discussed is AMFR; the disease is breast cancer.