MKI67 and cancer: This analysis highlights the association of gp78 protein expression with TNBC and other markers commonly associated with TNBC or more aggressive cancers, including cytoplasmic Kaiso (cKaiso) (11), epithelial growth factor receptor 1 (EGFR1), Ki-67, and LC3A/B (11), but also demonstrates non-TNBC clusters composed of a mixture of HER2, luminal A (LumA), and LumB subtypes that express high levels of gp78 (Figure 4A).