Interestingly, a similar proximity-based analysis of these linkages (Figure 8) shows that high gp78 is associated with both increased proximity of PD-L1+ CD8 and CD68 cells to tumor, as well as increased proximity of CD8 and CD68 cells near PD-L1+ tumor, suggesting an increased likelihood of immune suppression (Figure 8B). This evidence concerns the gene CD274 and neoplasm.