Importantly, the quantification of SR staining of collagen in the liver section also showed IFNAR1 blockade significantly reduced collagen deposition in the liver of HIV-infected mice with cART (Figure 6, F and G) and the assessment of liver fibrosis at 12–13 wpi by immunoblot revealed that IFNAR1 blockade significantly reduced the expression levels of α-SMA in the liver of HIV/cART animals (Figure 6H), indicating that IFN-I signaling critically contributes to HIV/cART-induced liver fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.