We also identified 6 rare missense variants in 9 patients with MIS-C (3 of whom also carried truncating variants from above analysis) in 5 of the 14 genes (IFNAR2 [OMIM 602376], IRF3 [OMIM 603734], TLR3 [OMIM 603029], TRAF3 [OMIM 608255], and TRIM69 [OMIIM 616017]) known to cause severe COVID-19 (Table) and none in the control group. This evidence concerns the gene IRF3 and COVID-19–associated multisystem inflammatory syndrome in children.