NFKB1 and COVID-19: Severely ill COVID-19 patients exhibit excessive mitochondrial ROS that lead to mitochondrial dysfunction, reducing the production and bioavailability of NO by the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), AP-1 as well as the overexpression of cytokines and adhesion molecules (Fig. 2) [90–92].