KCNH1 and Temple-Baraitser syndrome: Recent studies reported causative de novo heterozygous missense mutations involving this channel in developmental diseases that include Zimmermann-Laband syndrome 1 (ZLS1, MIM #135500) [27–29], Temple-Baraitser syndrome (TMBTS, MIM #611816) [30–32], syndromic intellectual disability [33] and syndromic developmental delay, hypotonia and seizures [34].