SCN10A and alkaline phosphatase measurement: Therefore, the aims of the present study were to: (1) to investigate the role of nociceptors (Nav1.8+ neurons) in the development of AP using transgenic selective nociceptor ablation and a well-established murine model of infection-induced AP, and (2) to evaluate TG nociceptors regulation of osteoblastic and osteoclastic function using an in vitro co-culture system.