LRRK2 and Parkinson disease: Also, histopathology in PD patients with LRRK2 mutations (PDLRRK2) is variable, including typical Lewy-body pathology, misfolded tau deposition, or nigral degeneration without Lewy-body (Zimprich et al. 2004; Heckman et al. 2016; Kalia et al. 2015).