SNCA and Parkinson disease: Moreover, penetrance and disease risk in PDGBA are age-dependent (Anheim et al. 2012; Straniero et al. 2020) and further modified by the composite PD-associated polygenetic risk score (PRS) and single-nucleotide polymorphisms in SNCA, CSTB and TMEM175, the two latter genes encoding proteins associated with lysosomal homeostasis and protein clearance (Blauwendraat et al. 2020b).