More strikingly, a recent publication could show that the small-molecule S-181 increases wild-type GCase activity in iPSC-derived dopaminergic neurons not only from PDGBA but also from PDwildtype as well as from patients with other PD-related gene mutations in LRRK2, DJ-1, and PARKN who also had decreased levels of GCase activity. The gene discussed is LRRK2; the disease is Parkinson disease.