Notably, the variant frequencies of APC and CREBBP exceeded 60%, whereas variants of FLNA, SRGAP3, TLE4, CDH11, TET1, TLL1, SALL4, FAM46C, FZD2, ARID2, INPP4B, and WAS were found exclusively in LS CRCs. This evidence concerns the gene TLE4 and Leigh syndrome.