Then, the legumain-sensitive site of PTX-released PPP (mPEG-PTP-7) was exposed and cut by legumain overexpressed in breast carcinoma and colorectal carcinoma, such as MCF-7, 4T1, and HCT116 cancer (Liu et al., 2014; Zhang & Lin, 2021), and finally releases PTP-7 to kill the tumor cell by cracking cell membrane (Figure 1). Here, LGMN is linked to breast carcinoma.