According toprevious studies, patients with TSC2 mutations usually have largeAML sizes and a high risk for AML hemorrhage (Cai etal., 2017; Li et al., 2018),whereas TSC patients with NMI are reported to have milder phenotypes than patientswith TSC2 mutations (Camposano etal., 2009). This evidence concerns the gene TSC2 and acute myeloid leukemia.