Neoplastic cells have been reported to variably expressneuronal and glial markers.28 Case reports in calves showed a lack of GFAP expression,2 diffuse positivity for the neuronal markers NSE and synaptophysin, andmultifocal labeling for S100.8 In the cases in this study, only the spindle-shaped cells showed positivityfor NSE and S100, which supported the diagnosis of medulloblastoma. Here, SYP is linked to medulloblastoma.