Moreover, chronic inflammation and increases in pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), which both contribute to cell proliferation in breast adipose stromal cells [23], may be a possible mechanism through which obesity contributes to worse health outcomes in diagnosed BC patients [30–32]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.