One example effect of one of these T1D-specific loci is that of rs4744112 located on chromosome 9, which influences CCR6+ CXCR3+ CCR4− Th1-like helper proportion (Figure 4B), with minor allele G leading to a decrease in these cells relative to major allele T (Figure 4C). This evidence concerns the gene CCR6 and type 1 diabetes mellitus.