To further validate the importance of chemokine signaling mediated by CCR5 in T1D, we illustrated the transcriptional changes on CCR5 and its corresponding ligand genes using publicly available data from transcriptome analysis in PBMCs and pancreatic tissue from T1D patients and controls (Planas et al., 2010; Yang et al., 2015) (see also Materials and methods). This evidence concerns the gene CCR5 and type 1 diabetes mellitus.