DPP4 and type 2 diabetes mellitus: In this light, we fill this gap in knowledge by conducting a head-to-head analysis and assessing the efficacy of the three-novel glucose-lowering drug classes (SGLT-2 inhibitors, GLP-1RAs and DPP-4 inhibitors) and their effectiveness on liver fat content i.e., HDL, LDL, triglycerides and total cholesterol in patients with T2DM with or without NAFLD as our primary outcome.