Valeska et al.'s studies in primary chronic lymphoblastic leukemia (CLL) showed that acyl protein thioesterases APT1 and APT2 regulated the depalmitoylation of Fas, and APT1 and APT2 in CLL cells caused the depalmitoylation of Fas, leading to Fas-mediated apoptotic resistance 57. Here, LYPLA1 is linked to B-cell chronic lymphocytic leukemia.