Yao et al. found that zDHHC3 could also palmitoylate PD-L1 on Cys272 in colon cancer, and the palmitoylated PD-L1 became more stable because it could not be degraded by the ubiquitination endosome pathway, weakening the immune killing effect of T cells in tumors. This evidence concerns the gene CD274 and malignant colon neoplasm.