Through flow cytometry, we found that the fluorescence intensities of CD163 and CD206 were significantly increased in macrophages after treating with exosomes derived from three RCC cell lines (789-O, ACHN and Caki-1) (Figure 3A-B), suggesting that the exosomes can promote macrophage M2 polarization in vivo. The gene discussed is MRC1; the disease is renal cell adenocarcinoma.