Besides, results of GSEA indicated that RPL23A might involve in Myc, E2F and G2M checkpoints pathways that were widely reported to have significant functions in tumorigenesis, cell cycle and cell proliferation that might favor to illustrate the functions of HERC3 on CRC cell proliferation and cell cycle (Figure 2A). The gene discussed is RPL23A; the disease is colorectal carcinoma.