Moreover, RPL23A was also revealed for the first time to be upregulated in CRC, besides, RPL23A upregulation predicted worse prognostic results, and RPL23A could independently regulate the CRC cell proliferation and cell cycle, furthermore, RPL23A could also partially attenuate the effects of HERC3 indicating that HERC3 might function through RPL23A. The gene discussed is HERC3; the disease is colorectal carcinoma.