However, researches demonstrating the effects of HERC3 on cancers are still rare, and it was demonstrated that HERC3 could mediate the ubiquitination degradation of SMAD7, further enhance autophagy-mediated epithelial-mesenchymal transition (EMT) and facilitate chemoresistance in glioblastoma 15. Here, SMAD7 is linked to glioblastoma.