Moreover, piR-54265/PIWIL2 complex interacted with signal transducer and activator of transcription 3 (STAT3) and phosphorylated-SRC (p-SRC) to form complex and activated STAT3 phosphorylation, in which both of them promoted CRC tumorigenesis 41, 42. The gene discussed is PIR; the disease is colorectal carcinoma.