CDKN2B and leukemia: Similarly, in the leukemia cell line U937, the CDKN2B-related has_piR_011186 constituted a complex with DNMT1, SUV39H1 and EZH2 proteins, upregulating the methylation level of DNA and histone H3 (including histone H3K9 and H3K27) in the CDKN2B promoter site.