In consistent with this, the transcription of FOXO1 was significantly higher and that of AQP3 was lower in basal than non-basal samples in the METABRIC dataset (p<1E-4, Supplementary Fig. 3B) according to Breast Cancer Gene-Expression Miner v4.5 (bc-GenExMiner) 28. This evidence concerns the gene FOXO1 and breast cancer.