Importantly, we validated such a negative correlation between FOXO1 and AQP3 at the protein expression level using 55 breast cancer clinical samples (Fig. 1O, Supplementary Fig. 3D, Supplementary Table 2), with the p value from the chi-squared test being 4.63E-20 and the correlation score being -0.54 (Fig. 1P). This evidence concerns the gene AQP3 and breast carcinoma.