Similarly, AQP3 had a lower expression in FOXO1-transfected SUM159PT (SUM159PT-FOXO1+) xenografts than in the control SUM159PT cells, and such an opposite relationship was also observed in in vivo mouse tumor samples after CAP treatment but with elevated AQP3 intensity (Fig. 1N). The gene discussed is AQP3; the disease is neoplasm.