For example, instead of directly taking actions, ·OH (~ 5 nm FDPL, ~ 1ns HLS) forms singlet oxygen (O21, ~250 nm FDPL, ~1μs HLT) or H2O2 (~1cm FDPL, ~20s HLS) 54, where O21 causes local inactivation of a few catalase molecules on tumor cell surface that triggers aquaporin-mediated H2O2 influx and tumor cell death, and H2O2 accumulates at the site of locally inactivated catalase together with ONOO- to generate additional O21 towards self-sustained auto-amplification and catalase inactivation 55. The gene discussed is CAT; the disease is neoplasm.