We report in this study that CAP can enhance IBRV propagation towards increased yield of vaccines against viral diseases through triggering cell selective autophagy and, in particular, mitophagy; this process is driven by the p-EGFR (Tyr1068)/p-Drp1(Ser616) signaling through physical interactions in response to CAP-induced cellular ROS level in a dose-dependent manner (Supplementary Figure 7A). Here, DNM1L is linked to viral infectious disease.