To explore the clinical relevance of UBE2S in PCa, we detected its protein expression in the SYSMH cohort (Cohort 1) (including 36 bone metastatic PCa tissues) and SYSUCC cohort (Cohort 2) (including 106 PCa tissues and 40 nontumour adjacent tissues) by immunohistochemistry. Here, UBE2S is linked to posterior cortical atrophy.