Emodin can downregulate key regulatory factors (such as β-catenin and TCF7L2) and their downstream targets (including cyclin D1, c-Myc, snail, vimentin, MMP-2 and MMP-9) in the Wnt signaling pathway to inhibit the migration and growth of the CRC cell lines SW480 and SW620. The gene discussed is MMP9; the disease is colorectal carcinoma.