Another research study showed that emodin could reduce the viability of A549 cells in a concentration-dependent manner through the induction of apoptosis via the activation of ER stress and the TRIB3/NF-κB pathway, and the antitumor effect of emodin was confirmed in an A549 tumor-bearing BALB/c nude mouse model in vivo48. The gene discussed is NFKB1; the disease is neoplasm.