TGFB1 and cervical carcinoma: It has been suggested that emodin can regulate TGF-β signaling in SiHa and HeLa cells and affect the growth, migration, and invasion of cervical cancer cells via downregulation of the TGF-β signaling pathway by reducing TGF-β receptor II and Smad4, inhibiting cyclin D1, P21 and Pin1, and downregulating Snail and Slug 200.