Emodin was found to be an effective inhibitor of the human 26S proteasome, which increased phosphorylation of STAT1, decreased phosphorylation of STAT3, increased endogenous gene expression stimulated by IFN-α, inhibited the degradation of type I interferon receptor 1 (IFNAR1), and enhanced the anti-proliferation effect of IFN-α on HeLa cervical cancer cells 193. This evidence concerns the gene IFNAR1 and cervical carcinoma.