In addition, emodin can inhibit the migration and adhesion of macrophages to the tumor site by inhibiting the secretion of MCP1 and CSF1 and the expression of THY-1 in tumor cells, suggesting that emodin can act on BC cells and macrophages simultaneously, effectively blocking the feedback loop between the two cells and exerting an antitumor effect 131. Here, CSF1 is linked to neoplasm.