CBX3 and familial pancreatic carcinoma: Additionally, GSEA based on the datasets ICGC-PACA (Pancreatic Cancer)-AU (Australia), ICGC-PACA-CA (Canada) and CPTAC-PDAC also demonstrated that CBX3 played an essential role in activating the TGF-β signaling pathway in pancreatic cancer (Fig. 4D-F).