As YBX1 regulated CBX3 expression in pancreatic cancer cells (Fig. 2), we knocked down and overexpressed YBX1 and found that YBX1 decreased the protein level of SMURF2 , which was attenutaed after co-knockdown of CBX3 (Fig. 6H-I). The gene discussed is CBX3; the disease is familial pancreatic carcinoma.