FADD and neoplasm: To validate tumor-suppressive effects of FADD loss (or oncogenic potential of FADD), we performed rescue experiments by overexpressing FADD or FADD-D (Serine 194 permanently replaced by Asparagine, mimicking pFADD which is a phosphorylated form of FADD at Serine 194) in FADD-/- Jurkat cells.