PADI4 and acute respiratory distress syndrome: Additionally, we observed significantly reduced inflammation and lung damage in PAD4-/-sepsis-associated ALI mice compared with those in PAD4+/+ sepsis-associated ALI mice, as indicated by significantly reduced inflammatory cell infiltration in the lung (Fig. 10A), a decreased wet-to-dry weight ratio of the lung (Fig. 10B) and a lower total cell number in BALF (Fig. 10C).